Phyllanthus amarus
[Carry Me Seed]

DSC09079 (08)

PB240001 (17)

DSC04991 (15)

DSC05001 (15)

DSC04995 (15)

Close-up views:

PB240002 (17)

P7170033 (22)

DSC05000 (15)
Plant Notes

| Last updated: December 2022 |

Based on an updated classification published in 2022 [1], Phyllanthus amarus is now being designated as a basionym of Moeroris amara. Indeed, the Flora & Fauna Web by NParks had already migrated to the newly assigned name when I viewed the page on 31 December 2022.


[1] Bouman RW, Kebler PJA, Telford IRH, Bruhl JJ, Strijk JS, Saunders RMK, Esser H, Falcón-Hidalgo B, Van PC. A revised phylogenetic classification of tribe Phyllantheae (Phyllanthaceae). Phytotaxa 2022;540(1):1-100. | Read article |

Online Resources

| Plants of the World Online | Urban Forest | GlobinMed | Flora of North America |


[2022] Sparzak-Stefanowska B, Krauze-Baranowska M. Phyllanthus amarus shoot cultures as a source of biologically active lignans: the influence of selected plant growth regulators. Sci Rep 2022;12(1):11505. | Read article |

[2022] Afolabi AO, Akhigbe TM, Odetayo AF, Anyogu DC, Hamed MA, Akhigbe RE. Restoration of hepatic and intestinal integrity by Phyllanthus amarus is dependent on Bax/Caspase 3 modulation in intestinal ischemia-/reperfusion-induced injury. Molecules 2022;27(16):5073. | Read article |

[2022] Bose Mazumdar Ghosh A, Banerjee A, Chattopadhyay S. An insight into the potent medicinal plant Phyllanthus amarus Schum. and Thonn. Nucleus (Calcutta) 2022;65(3):437-472. | Read article |

[2022] Faloye KO, Mahmud S, Fakola EG, Oyetunde YM, Fajobi SJ, Ugwo JP, Olusola AJ, Famuyiwa SO, Olajubutu OG, Oguntade TI, Obaidullah AJ. Revealing the acetylcholinesterase inhibitory potential of Phyllanthus amarus and its phytoconstituents: in vitro and in silico approach. Bioinform Biol Insights 2022;16:11779322221118330. | Read article |

[2021] Hiremath S, Kumar HDV, Nandan M, Mantesh M, Shankarappa KS, Venkataravanappa V, Basha CRJ, Reddy CNL. In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2. 3 Biotech 2021;11(2):44. | Read article |

[2021] Abd Rani NZ, Lam KW, Jalil J, Mohamad HF, Mat Ali MS, Husain K. Mechanistic studies of the antiallergic activity of Phyllanthus amarus Schum. & Thonn. and its compounds. Molecules 2021;26(3):695. | Read article |

[2021] Olorunnisola OS, Fadahunsi OS, Adegbola PI, Ajilore BS, Ajayi FA, Olaniyan LWB. Phyllanthus amarus attenuated derangement in renal-cardiac function, redox status, lipid profile and reduced TNF-α, interleukins-2, 6 and 8 in high salt diet fed rats. Heliyon 2021;7(10):e08106. | Read article |

[2021] Buddhachat K, Paenkaew S, Sripairoj N, Gupta YM, Pradit W, Chomdej S. Bar-cas12a, a novel and rapid method for plant species authentication in case of Phyllanthus amarus Schumach. & Thonn. Sci Rep 2021;11(1):20888. | Read article |

[2021] Nguyen VT. Antiproliferative capacity of combined extracts from Paramignya trimera and Phyllanthus amarus against cancer cell lines. J Cancer Res Ther 2021;17(2):471-476. | Read article |

[2021] Chopade AR, Pol RP, Patil PA, Dharanguttikar VR, Naikwade NS, Dias RJ, Mali SN. An insight into the anxiolytic effects of lignans (phyllanthin and hypophyllanthin) and tannin (corilagin) rich extracts of Phyllanthus amarus: an in-silico and in-vivo approaches. Comb Chem High Throughput Screen 2021;24(3):415-422. | Read abstract |

[2021] Mohamed SIA, Jantan I, Nafiah MA, Seyed MA, Chan KM. Lignans and polyphenols of Phyllanthus amarus Schumach and Thonn induce apoptosis in HCT116 human colon cancer cells through caspases-dependent pathway. Curr Pharm Biotechnol 2021;22(2):262-273. | Read abstract |

[2020] Ismail EN, Jantan I, Vidyadaran S, Jamal JA, Azmi N. Phyllanthus amarus prevents LPS-mediated BV2 microglial activation via MyD88 and NF-κB signaling pathways. BMC Complement Med Ther 2020;20(1):202. | Read article |

[2020] Tao Z, Chun-Yan H, Hua P, Bin-Bin Y, Xiaoping T. Phyllathin From Phyllanthus amarus ameliorates epileptic convulsion and kindling associated post-ictal depression in mice via inhibition of NF-κB/TLR-4 pathway. Dose Response 2020;18(3):1559325820946914. | Read article |

[2020] Ogunmoyole T, Awodooju M, Idowu S, Daramola O. Phyllanthus amarus extract restored deranged biochemical parameters in rat model of hepatotoxicity and nephrotoxicity. Heliyon 2020;6(12):e05670. | Read article |

[2020] Harikrishnan H, Jantan I, Alagan A, Haque MA. Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer. Inflammopharmacology 2020;28(1):1-18. | Read abstract |

[2019] Paul S, Patra D, Kundu R. Lignan enriched fraction (LRF) of Phyllanthus amarus promotes apoptotic cell death in human cervical cancer cells in vitro. Sci Rep 2019;9(1):14950. | Read article |

[2019] Alagan A, Jantan I, Kumolosasi E, Azmi N. Phyllanthus amarus protects against spatial memory impairment induced by lipopolysaccharide in mice. Bioinformation 2019;15(8):535-541. | Read article |

[2019] Alagan A, Jantan I, Kumolosasi E, Ogawa S, Abdullah MA, Azmi N. Protective effects of Phyllanthus amarus against lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats. Front Pharmacol 2019;10:632. | Read article |

[2019] George A, Udani JK, Yusof A. Effects of Phyllanthus amarus PHYLLPRO leaves on hangover symptoms: a randomized, double-blind, placebo-controlled crossover study. Pharm Biol 2019;57(1):145-153. | Read article |

[2019] Nguyen VT, Scarlett CJ. Cytotoxic activity of extracts and fractions from Paramignya trimera root and Phyllanthus amarus against pancreatic cancer cell lines. J Cancer Res Ther 2019;15(1):245-249. | Read article |

[2019] Wu W, Li Y, Jiao Z, Zhang L, Wang X, Qin R. Phyllanthin and hypophyllanthin from Phyllanthus amarus ameliorates immune-inflammatory response in ovalbumin-induced asthma: role of IgE, Nrf2, iNOs, TNF-α, and IL's. Immunopharmacol Immunotoxicol 2019;41(1):55-67. | Read abstract |

[2018] Mohamed SIA, Jantan I, Nafiah MA, Seyed MA, Chan KM. Dendritic cells pulsed with generated tumor cell lysate from Phyllanthus amarus Schum. & Thonn. induces anti-tumor immune response. BMC Complement Altern Med 2018;18(1):232. | Read article |

[2018] Yao AN, Kamagaté M, Amonkan AK, Chabert P, Kpahé F, Koffi C, Kouamé MN, Auger C, Kati-Coulibaly S, Schini-Kerth V, Die-Kakou H. The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins. BMC Complement Altern Med 2018;18(1):94. | Read article |

[2018] Harikrishnan H, Jantan I, Haque MA, Kumolosasi E. Anti-inflammatory effects of Phyllanthus amarus Schum. & Thonn. through inhibition of NF-κB, MAPK, and PI3K-Akt signaling pathways in LPS-induced human macrophages. BMC Complement Altern Med 2018;18(1):224. | Read article |

[2018] Harikrishnan H, Jantan I, Haque MA, Kumolosasi E. Phyllanthin from Phyllanthus amarus inhibits LPS-induced proinflammatory responses in U937 macrophages via downregulation of NF-κB/MAPK/PI3K-Akt signaling pathways. Phytother Res 2018;32(12):2510-2519. | Read abstract |

[2018] Alam J, Jantan I, Kumolosasi E, Nafiah MA, Mesaik MA. Suppressive effects of the standardized extract of Phyllanthus amarus on type II collagen-induced rheumatoid arthritis in Sprague Dawley rats. Curr Pharm Biotechnol 2018;19(14):1156-1169. | Read abstract |

[2017] Nguyen VT, Sakoff JA, Scarlett CJ. Physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from Phyllanthus amarus. Medicines (Basel) 2017;4(2):42. | Read article |

[2016] Yuandani, Jantan I, Ilangkovan M, Husain K, Chan KM. Inhibitory effects of compounds from Phyllanthus amarus on nitric oxide production, lymphocyte proliferation, and cytokine release from phagocytes. Drug Des Devel Ther 2016;10:1935-1945. | Read article |

[2016] Ilangkovan M, Jantan I, Bukhari SN. Phyllanthin from Phyllanthus amarus inhibits cellular and humoral immune responses in Balb/C mice. Phytomedicine 2016;23(12):1441-1450. | Read abstract |

[2016] Ilangkovan M, Jantan I, Mesaik MA, Bukhari SN. Inhibitory Effects of the standardized extract of Phyllanthus amarus on cellular and humoral immune responses in Balb/C mice. Phytother Res 2016;30(8):1330-1338. | Read abstract |

[2015] Bose Mazumdar A, Chattopadhyay S. Sequencing, De novo Assembly, Functional annotation and analysis of Phyllanthus amarus leaf transcriptome using the illumina platform. Front Plant Sci 2016;6:1199. | Read article |

[2015] Sparzak B, Krauze-Baranowska M, Kawiak A, Sowiński P. Cytotoxic lignan from the non-transformed root culture of Phyllanthus amarus. Molecules 2015;20(5):7915-7924. | Read article |

[2015] Ilangkovan M, Jantan I, Mesaik MA, Bukhari SN. Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats. Drug Des Devel Ther 2015;9:4917-4930. | Read article |

[2015] Chopade AR, Sayyad FJ. Pain modulation by lignans (phyllanthin and hypophyllanthin) and tannin (corilagin) rich extracts of Phyllanthus amarus in carrageenan-induced thermal and mechanical chronic muscle hyperalgesia. Phytother Res 2015;29(8):1202-1210. | Read abstract |

[2015] Buddhachat K, Osathanunkul M, Madesis P, Chomdej S, Ongchai S. Authenticity analyses of Phyllanthus amarus using barcoding coupled with HRM analysis to control its quality for medicinal plant product. Gene 2015;573(1):84-90. | Read abstract |

[2013] Yuandani, Ilangkovan M, Jantan I, Mohamad HF, Husain K, Abdul Razak AF. Inhibitory effects of standardized extracts of Phyllanthus amarus and Phyllanthus urinaria and their marker compounds on phagocytic activity of human neutrophils. Evid Based Complement Alternat Med 2013;2013:603634. | Read article |

[2013] Maity S, Nag N, Chatterjee S, Adhikari S, Mazumder S. Bilirubin clearance and antioxidant activities of ethanol extract of Phyllanthus amarus root in phenylhydrazine-induced neonatal jaundice in mice. J Physiol Biochem 2013;69(3):467-476. | Read abstract |

[2012] Xavier JR, Gnanam R, Murugan MP, Pappachan A. Clonal propagation of Phyllanthus amarus: A hepatoprotector. Pharmacogn Mag 2012;8(29):78-82. | Read article |

[2012] Deepa V, Sridhar R, Goparaju A, Reddy PN, Murthy PB. Nanoemulsified ethanolic extract of Pyllanthus amarus Schum & Thonn ameliorates CCl4 induced hepatotoxicity in Wistar rats. Indian J Exp Biol 2012;50(11):785-794. | Read abstract |

[2012] Poompachee K, Chudapongse N. Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. Med Princ Pract 2012;21(1):24-29. | Read abstract |

[2011] Eweka A, Enogieru A. Effects of oral administration of Phyllanthus amarus leaf extract on the kidneys of adult wistar rats: a histological study. Afr J Tradit Complement Altern Med 2011;8(3):307-311. | Read article |

[2011] Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK. Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review. J Ethnopharmacol 2011;138(2):286-313. | Read abstract |

[2010] Adjene JO, Nwose EU. Histological effects of chronic administration of Phyllanthus amarus on the kidney of adult Wistar rat. N Am J Med Sci 2010;2(4):193-195. | Read article |

[2010] Manissorn J, Sukrong S, Ruangrungsi N, Mizukami H. Molecular phylogenetic analysis of Phyllanthus species in Thailand and the application of polymerase chain reaction-restriction fragment length polymorphism for Phyllanthus amarus identification. Biol Pharm Bull 2010;33(10):1723-1727. | Read article |

[2009] Singh M, Tiwari N, Shanker K, Verma RK, Gupta AK, Gupta MM. Two new lignans from Phyllanthus amarus. J Asian Nat Prod Res 2009;11(6):562-568. | Read abstract |

[2008] Yadav NP, Pal A, Shanker K, Bawankule DU, Gupta AK, Darokar MP, S Khanuja SP. Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus. Phytomedicine 2008;15(12):1053-1061. | Read abstract |

[2008] Faremi TY, Suru SM, Fafunso MA, Obioha UE. Hepatoprotective potentials of Phyllanthus amarus against ethanol-induced oxidative stress in rats. Food Chem Toxicol 2008;46(8):2658-2664. | Read abstract |

[2008] Adeneye AA, Benebo AS. Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats. J Ethnopharmacol 2008;118(2):318-323. | Read abstract |

[2007] Naaz F, Javed S, Abdin MZ. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice. J Ethnopharmacol 2007;113(3):503-509. | Read abstract |

[2007] Pramyothin P, Ngamtin C, Poungshompoo S, Chaichantipyuth C. Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: in vitro and in vivo studies. J Ethnopharmacol 2007;114(2):169-173. | Read abstract |

[2007] Harikumar KB, Kuttan R. An extract of Phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages. J Radiat Res 2007;48(6):469-476. | Read abstract |

[2006] Leite DF, Kassuya CA, Mazzuco TL, Silvestre A, de Melo LV, Rehder VL, Rumjanek VM, Calixto JB. The cytotoxic effect and the multidrug resistance reversing action of lignans from Phyllanthus amarus. Planta Med 2006;72(15):1353-1358. | Read abstract |

[2006] Kassuya CA, Silvestre A, Menezes-de-Lima O Jr, Marotta DM, Rehder VL, Calixto JB. Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor. Eur J Pharmacol 2006;546(1-3):182-188. | Read abstract |

[2005] Kassuya CA, Leite DF, de Melo LV, Rehder VL, Calixto JB. Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus. Planta Med 2005;71(8):721-726. | Read abstract |

[2005] Kumar KB, Kuttan R. Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice. Phytomedicine 2005;12(6-7):494-500. | Read abstract |

[2004] Kumar KB, Kuttan R. Protective effect of an extract of Phyllanthus amarus against radiation-induced damage in mice. J Radiat Res 2004;45(1):133-139. | Read abstract |

[2001] Bhattacharyya R, Bhattacharya S. High frequency in vitro propagation of Phyllanthus amarus Schum. & Thom. by shoot tip culture. Indian J Exp Biol 2001;39(11):1184-1187. | Read abstract |

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